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Alpha-2-macroglobulin is a protease inhibitor and is 1 of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system.
Mar 25, 2013 Increase. 100-280mg per 100 ml of serum is the normal level of Alpha 2. It is elevated in inflammation and nephrotic syndrome. However, all lab results need to be interpreted in the clinical test and the doctor who ordered the test is in the best position to do that. See this more info. Recent FibroSure test results showed that I had elevated Alpha 2 Macroglobulins (303H). My FibroSure test score was 0.22, fibrosis stage: F0-F1 and necroinflammatory activity 0.17. What do these figure.
Alpha 2 Macroglobulin Antibody
Increased levels of alpha-2-macroglobulin are found in nephrotic syndrome when other lower molecular weight proteins are lost and alpha-2-macroglobulin is retained because of its large size. In patients with liver cirrhosis and diabetes, the levels are found to be elevated.
Patients with acute pancreatitis exhibit low serum concentrations which correlate with the severity of the disease. In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of alpha-2-macroglobulin are often low. Acute myocardial infarction patients with low alpha-2-macroglobulin have been reported to have a significantly better prognosis with regard to the greater than a year survival time.
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